晚期头颈部鳞状细胞癌的联合化疗

Combination chemotherapy for advanced squamous cell carcinoma of the head and neck.

作者信息

Coker D D, Elias E G, Chretien P B, Gray W C, Coleman J J, Zentai T A, Didolkar M S, Morris D M, Viravathana T, Hebel J R

出版信息

Head Neck Surg. 1981 Nov-Dec;4(2):111-7. doi: 10.1002/hed.2890040205.

DOI:10.1002/hed.2890040205

PMID:6171545

Abstract

Fifty-one patients (32 previously untreated, 19 previously treated) with advanced squamous cell carcinoma of the head and neck received a single course of combination chemotherapy consisting of high dose cis-platinum (DDP), bleomycin (Bleo), +/- high dose methotrexate (MTX). Thirty-three (65%) patients responded to therapy; 5 (10%) of these patients had a complete response. Previously untreated patients and those who received the three drugs (DDP, Bleo and MTX) had the highest response rates. The duration of response was 8 to 12 weeks. Seven (15%) patients showed a two-year survival rate. All nonresponders were dead of disease within two years. Three (56%) of the five complete-response patients and 4 (21%) of the partial-response patients survived for two years. The role of preoperative chemotherapy in head and neck cancer is yet to be conclusively defined.

摘要

51例晚期头颈部鳞状细胞癌患者（32例既往未接受过治疗，19例既往接受过治疗）接受了一个疗程的联合化疗，化疗方案包括高剂量顺铂（DDP）、博来霉素（Bleo），±高剂量甲氨蝶呤（MTX）。33例（65%）患者对治疗有反应；其中5例（10%）患者完全缓解。既往未接受过治疗的患者以及接受三种药物（DDP、Bleo和MTX）治疗的患者缓解率最高。缓解持续时间为8至12周。7例（15%）患者显示出两年生存率。所有无反应者在两年内均死于疾病。5例完全缓解患者中有3例（56%）以及部分缓解患者中有4例（21%）存活了两年。术前化疗在头颈癌中的作用尚未最终确定。