Milman N
Clin Nephrol. 1981 Dec;16(6):314-20.
The relations between plasma transferrin, iron status and plasma albumin were studied in 76 patients with chronic uremia (23 non-dialyzed, 18 peritoneal dialyzed and 35 hemodialyzed). Patients with reduced (grade O) hemosiderin marrow iron had higher plasma transferrin (P less than 0.001), lower serum iron (P less than 0.01), transferrin saturation (P less tha 0.001) and serum ferritin (P less than 0.001), and higher iron absorption (P less than 0.001) than patients with "normal" (grade 1+) marrow iron. There were no significant differences between transferrin levels in the three groups of uremic subjects, when patients with identical marrow iron grade were compared. Plasma transferrin was correlated both to serum ferritin (r = -0.59, P less than 0.001) and iron absorption (r = 0.56, P less than 0.001). Patients with grade O marrow iron had normal transferrin levels compared with a healthy control group of 75 subjects, while levels in patients with grade 1+ marrow iron were lower than in controls (P less than 0.001). Plasma albumin displayed significant variations between the groups, being almost normal in non-dialyzed, slightly lower in hemodialyzed and lowest in peritoneal dialyzed patients. There was no correlation between plasma transferrin and plasma albumin. Due to its close association with iron metabolism, plasma transferrin is unsuitable as a marker of protein depletion, whereas plasma albumin seems to be a better indicator of protein status in uremic subjects.
对76例慢性尿毒症患者（23例未透析、18例腹膜透析和35例血液透析）的血浆转铁蛋白、铁状态和血浆白蛋白之间的关系进行了研究。与骨髓铁“正常”（1+级）的患者相比，含铁血黄素骨髓铁减少（O级）的患者血浆转铁蛋白水平更高（P<0.001），血清铁更低（P<0.01），转铁蛋白饱和度更低（P<0.001），血清铁蛋白更低（P<0.001），铁吸收更高（P<0.001）。当比较骨髓铁分级相同的患者时，三组尿毒症患者的转铁蛋白水平无显著差异。血浆转铁蛋白与血清铁蛋白（r = -0.59，P<0.001）和铁吸收（r = 0.56，P<0.001）均相关。与75名健康对照者组成的对照组相比，骨髓铁O级的患者转铁蛋白水平正常，而骨髓铁1+级的患者转铁蛋白水平低于对照组（P<0.001）。各组间血浆白蛋白有显著差异，未透析患者的血浆白蛋白几乎正常，血液透析患者略低，腹膜透析患者最低。血浆转铁蛋白与血浆白蛋白之间无相关性。由于血浆转铁蛋白与铁代谢密切相关，因此它不适宜作为蛋白质消耗的标志物，而血浆白蛋白似乎是尿毒症患者蛋白质状态的更好指标。
