Milman N
Clin Nephrol. 1982 Feb;17(2):77-81.
Iron absorption was measured by whole body counting, using 10 microCI 59Fe3+ and 10 mg Fe2+ as carrier, in 53 patients with chronic uremia (16 non-dialyzed, 18 peritoneal dialyzed, 19 hemodialyzed) and in 14 renal transplanted patients having normal kidney function. Bone marrow hemosiderin iron was assessed semiquantitatively after staining with Prussian blue, Iron absorption was clearly dependent on iron stores, being higher in patients with reduced marrow iron than in patients with adequate marrow iron stores (P less than 0.01) Hemodialysis patients had greater blood losses and significantly higher absorption than both non-dialysis and peritoneal dialysis patients. There were significant correlation between iron absorption and plasma transferrin (r = 0.56, P less then 0.001); and between log iron absorption and log serum ferritin (r = 0.80, P less than 0.01) in peritoneal dialysis patients. The results indicate that the regulatory mechanism which relates iron absorption to body iron stores is intact in patients with chronic uremia.
采用全身计数法，以10微居里的59Fe3 +和10毫克Fe2 +作为载体，对53例慢性尿毒症患者（16例未透析、18例腹膜透析、19例血液透析）以及14例肾功能正常的肾移植患者的铁吸收情况进行了测量。用普鲁士蓝染色后对骨髓含铁血黄素铁进行半定量评估。铁吸收明显依赖于铁储备，骨髓铁减少的患者比骨髓铁储备充足的患者铁吸收更高（P <0.01）。血液透析患者的失血更多，其铁吸收明显高于未透析和腹膜透析患者。腹膜透析患者的铁吸收与血浆转铁蛋白之间存在显著相关性（r = 0.56，P <0.001）；铁吸收对数与血清铁蛋白对数之间也存在显著相关性（r = 0.80，P <0.01）。结果表明，慢性尿毒症患者中，将铁吸收与体内铁储备相关联的调节机制是完整的。
