Paretsky D, Gonzales F R, Berquist K
J Gen Microbiol. 1981 Feb;122(2):227-33. doi: 10.1099/00221287-122-2-227.
Temporal studies were made of factors associated with increased RNA synthesis in guinea pig liver during Q fever. DNA-dependent RNA polymerase activities increased immediately after infection. The major distribution of RNA polymerase classes shifted from class II to class I during infection. Ornithine decarboxylase activity was induced or stimulated soon after infection and remained elevated throughout the four-day period studied. S-Adenosylmethionine decarboxylase activity increased on the first day after infection and subsequently declined. Concomitantly elevated concentrations of the polyamines putrescine, spermidine and spermine reached a maximum on the first day after infection and then decreased. A model is presented to integrate these and other results to explain how RNA synthesis may be regulated during infection.
对Q热期间豚鼠肝脏中与RNA合成增加相关的因素进行了时间研究。感染后DNA依赖性RNA聚合酶活性立即增加。在感染期间，RNA聚合酶类别的主要分布从II类转移到I类。感染后不久鸟氨酸脱羧酶活性被诱导或刺激，并在整个研究的四天期间保持升高。S-腺苷甲硫氨酸脱羧酶活性在感染后的第一天增加，随后下降。多胺腐胺、亚精胺和精胺的浓度同时升高，在感染后的第一天达到最大值，然后下降。提出了一个模型来整合这些及其他结果，以解释感染期间RNA合成可能是如何被调控的。
