[Identification and characteristics of steroid hormone receptor binding properties in the nuclear fraction of human prostatic adenoma].

Steroid receptors in adenoma nuclear fraction of the human prostate were studied. Androgen and progestin receptors were revealed in 0.4 KCl nuclear extracts. The measured association constant values were 6.05 +/- 1.45 X 10(9) M-1 and 2.08 +/- 0.37 X 10(9) M-1 for 5 alpha-dihydrotestosterone and progesterone, respectively. Only 5 alpha-dihydrotestosterone and testosterone competed markedly with 3H-5 alpha-dihydrotestosterone, hormonal specificity of 3H-progesterone binding affinity being less pronounced. Specific estradiol binding being found in several adenomas was very low. Glucocorticoid receptors were not detected.