Piccirilli M, Piccinin G L, Lamedica A
Riv Patol Nerv Ment. 1981 Sep-Oct;101(5):225-46.
A literature review shows that patients affected by Parkinson's disease present an intellectual impairment more frequently than the comparably aged population. Such impairment has been related to several factors (age, arteriosclerosis, motor difficulties, depression, dopaminergic therapy, cortical and/or subcortical lesions). Parkinsonian dementia may be caused by the extent of the degenerative process. Our own results show that parkinsonian patients with dementia are different from nondemented ones with the following features: a) a more marked bradykinesia b) a more severe extrapyramidal picture c) a progressive unresponsiveness to levodopa in a shorter time. It seems possible that there is a Parkinson syndrome characterized, clinically, by an intellectual impairment with a poor prognosis quoad valetudinem, and, anatomically, with multiple cortical and subcortical lesions. Such syndrome may be a "transition" form between Parkinson disease and senile-presenile dementia.
一项文献综述表明，帕金森病患者比同龄人群更常出现智力障碍。这种障碍与多种因素有关（年龄、动脉硬化、运动困难、抑郁、多巴胺能治疗、皮质和/或皮质下病变）。帕金森病痴呆可能由退行性病变的程度引起。我们自己的研究结果表明，患有痴呆的帕金森病患者与未患痴呆的患者在以下方面存在差异：a）更明显的运动迟缓；b）更严重的锥体外系症状；c）在更短时间内对左旋多巴逐渐无反应。似乎可能存在一种帕金森综合征，在临床上以智力障碍为特征，预后较差，在解剖学上表现为多处皮质和皮质下病变。这种综合征可能是帕金森病和老年 - 早老性痴呆之间的一种“过渡”形式。
