Hornstein A, Salzberg S, Pluznik D H
Exp Hematol. 1982 Feb;10(2):178-86.
The present study provides direct evidence for a correlation between mitogenicity and induction of type C particles (virogenic activity) in cultures stimulated by LPS. This evidence is based on the following observations: 1) The complex of the antibiotic polymyxin B with LPS (LPS-PB) inhibits mitogenicity and virogenic activity in spleen cell cultures from BALB/c mice, but does not inhibit the generation of colony stimulating factor (CSF) from such cultures; 2) CBA/N, a genetically-defective mouse strain in its mitogenic response to LPS, was also defective in virus induction by LPS, but generated high levels of LPS-induced CSF.
本研究为脂多糖（LPS）刺激培养物中的促有丝分裂活性与C型颗粒诱导（病毒原性活性）之间的相关性提供了直接证据。该证据基于以下观察结果：1）抗生素多粘菌素B与LPS的复合物（LPS-PB）抑制BALB/c小鼠脾细胞培养物中的促有丝分裂活性和病毒原性活性，但不抑制此类培养物中集落刺激因子（CSF）的产生；2）CBA/N是一种对LPS的促有丝分裂反应存在基因缺陷的小鼠品系，在LPS诱导病毒方面也存在缺陷，但能产生高水平的LPS诱导的CSF。
