Knight R A, Fitzharris P
Immunology. 1982 Mar;45(3):513-9.
Two populations of human blood lymphocytes--one forming rosettes with sheep erythrocytes, the other non-rosetting--are cytolytic in vitro for several long term cultured tumour-derived cell lines. A particular breast cancer-derived target cell (MDA-157) is only killed by the non-rosetting effector. Rosetting cells from normal donors infected or immunized with influenza virus augment cytolytic activity on MDA-157 targets by non-rosetting effector cells. Similar augmenting activity can be induced by incubating the rosetting population with sources of immune (gamma), but not leucocyte (alpha) interferon in vitro. This augmentation of cytolytic activity does not require compatibility at the major histocompatibility locus between the augmenting and effector populations.
人类血液淋巴细胞有两类群体——一类能与绵羊红细胞形成玫瑰花结,另一类则不能形成玫瑰花结——在体外对几种长期培养的肿瘤衍生细胞系具有细胞溶解作用。一种特定的源自乳腺癌的靶细胞(MDA - 157)仅被不能形成玫瑰花结的效应细胞杀死。来自感染或接种流感病毒的正常供体的能形成玫瑰花结的细胞,可增强不能形成玫瑰花结的效应细胞对MDA - 157靶细胞的细胞溶解活性。通过在体外将能形成玫瑰花结的细胞群体与免疫(γ)干扰素而非白细胞(α)干扰素来源一起孵育,可诱导出类似的增强活性。这种细胞溶解活性的增强并不要求增强细胞群体与效应细胞群体在主要组织相容性位点上具有相容性。