系统性红斑狼疮患者自然杀伤细胞对干扰素不敏感。
Insensitivity to interferon of NK cells from patients with systemic lupus erythematosus.
作者信息
Fitzharris P, Alcocer J, Stephens H A, Knight R A, Snaith M L
出版信息
Clin Exp Immunol. 1982 Jan;47(1):110-8.
Abstract
Natural cytotoxicity (NK) by fresh E-rosette-negative (ER-) cells from normal donors was increased after overnight incubation with purified IFN alpha and with supernatants containing IFN gamma. ER- cells from 61% of 23 patients with systemic lupus erythematosus did not show increased cytotoxicity after treatment with IFN alpha. Similarly, ER- cells from nine of 18 patients that were treated with IFN gamma-containing supernatants failed to show increased cytotoxicity. The patients who did not show enhanced cytotoxic responses to IFN had higher mean indices of disease activity than responding patients.
摘要
来自正常供体的新鲜E花环阴性（ER-）细胞的自然细胞毒性（NK）在与纯化的干扰素α以及含有干扰素γ的上清液过夜孵育后增强。23例系统性红斑狼疮患者中61%的ER-细胞在用干扰素α处理后未表现出细胞毒性增强。同样，在用含干扰素γ的上清液处理的18例患者中，有9例的ER-细胞未表现出细胞毒性增强。对干扰素未表现出增强的细胞毒性反应的患者，其疾病活动平均指数高于有反应的患者。
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