Dimopoulos C, Fertakis A, Stathopoulos C, Goulandris N, Kastriotis J, Antipas A, Melissinos K
J Urol (Paris). 1982;88(1):11-3.
beta 2 Microglobulin is a low molecular weight protein synthesised by lymphocytes and neoplastic cells. The authors measured levels of this substance in the plasma of 40 patients with carcinoma of the bladder and normal renal function. 26 subjects were used as controls. Plasma levels were markedly higher in the bladder carcinoma sufferers than in the normal controls. Levels were also higher in invasive carcinomas than in superficial lesions. beta 2 microglobulin may therefore not be considered to be a specific indicator of carcinoma of the bladder but rather as a factor offering the possibility of measurement of the secretory activity of tumour cells.
β2微球蛋白是一种由淋巴细胞和肿瘤细胞合成的低分子量蛋白质。作者测定了40例膀胱肿瘤且肾功能正常患者血浆中该物质的水平。26名受试者作为对照。膀胱癌患者血浆水平明显高于正常对照组。浸润性癌患者的水平也高于浅表性病变患者。因此，β2微球蛋白可能不能被视为膀胱癌的特异性指标，而更应被看作是一种能够测量肿瘤细胞分泌活性的因素。
