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[神经系统肿瘤蛋白。胶质纤维酸性蛋白和透明质酸结合素(作者译)]

[Nervous system tumour proteins. G.F.A. and hyaluronectin (author's transl)].

作者信息

Delpech B, Girard N, Courel M N, Delpech A, Tayot J, Creissard P

出版信息

Neurochirurgie. 1981;27(5):257-9.

PMID:6174875
Abstract

G.F.A. (gliofibrillary acid protein) and hyaluronectin studied here are two antigens defined by the heteroantibodies which appear in the serum of the immunised animal. G.F.A. is associated with gliofilaments and is considered as an astrocyte marker, either normal or tumoral. Hyaluronectin, is found in the Ranvier nodes and at the periphery of neurones. It is not specific to the nervous system. It is found in all tissues and tumors, and in particular marks the intercellular spaces of gliomas, where it is associated with hyaluronic acid for which it has a great affinity. Serum estimation of these Proteins is being undertaken with the view to a clinical application.

摘要

本文研究的神经胶质纤维酸性蛋白(G.F.A.)和透明质连接蛋白是由免疫动物血清中出现的异种抗体所定义的两种抗原。G.F.A. 与神经胶质丝相关,被视为正常或肿瘤性星形胶质细胞的标志物。透明质连接蛋白存在于郎飞结和神经元外周。它并非神经系统所特有。在所有组织和肿瘤中均可发现,尤其在胶质瘤的细胞间隙有明显标记,在那里它与具有高亲和力的透明质酸相关。目前正在对这些蛋白质进行血清检测,以期用于临床。

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