Janicki P, Lypko A, Szczudlik A, Libich J
Pol J Pharmacol Pharm. 1981;33(5):499-502.
The content of substance P(SP) in the rat forebrain was assayed by radioimmunoassay technique after apomorphine and haloperidol injection. Apomorphine (1 and 10 mg/kg) produced dose-dependent decrease in SP content, while haloperidol, 0.2 and 1 mg/kg produced a marked increase in SP level in the forebrain. The results may suggest a modulatory role for SP in the action of dopamine receptor agonists and antagonists.
采用放射免疫分析技术测定阿扑吗啡和氟哌啶醇注射后大鼠前脑P物质（SP）的含量。阿扑吗啡（1和10mg/kg）使SP含量呈剂量依赖性降低，而氟哌啶醇（0.2和1mg/kg）使前脑SP水平显著升高。结果提示SP在多巴胺受体激动剂和拮抗剂的作用中起调节作用。
