Golub S H, Dorey F, Hara D, Morton D L, Burk M W
J Natl Cancer Inst. 1982 May;68(5):703-10.
Natural killer (NK) cytotoxicity was assessed against K562 targets in 14 melanoma patients who received daily im doses of human leukocyte interferon (IFN) for 42 consecutive days. The most common pattern of NK activity was a decline from pretreatment levels 1 day after initiation of treatment, followed by increasing cytotoxicity with peak activity at day 7 and a subsequent gradual decline to pretreatment levels during the remaining weeks of treatment. This pattern was particularly apparent in patients who received 3 x 10(6) or 9 x 10(6) U IFN/day, while patients who received 1 X 10(6) U IFN/day tended to lack the decline at day 1 and maintained the elevated NK activity past day 7. Changes in NK activity could not be related to changes in absolute lymphocyte counts; to proportions of cells bearing membrane receptors for erythrocyte-antibody-complement, of cells bearing FC gamma receptor; or to clinical response to IFN.
在14名黑色素瘤患者中评估了自然杀伤（NK）细胞对K562靶标的细胞毒性，这些患者连续42天每天接受皮下注射人白细胞干扰素（IFN）。最常见的NK活性模式是治疗开始后1天从治疗前水平下降，随后细胞毒性增加，在第7天达到峰值活性，随后在治疗的剩余几周内逐渐下降至治疗前水平。这种模式在每天接受3×10⁶或9×10⁶U IFN的患者中尤为明显，而每天接受1×10⁶U IFN的患者在第1天往往没有下降，并且在第7天后NK活性持续升高。NK活性的变化与绝对淋巴细胞计数的变化、带有红细胞抗体补体膜受体的细胞比例、带有Fcγ受体的细胞比例或对IFN的临床反应无关。
