Harron D W, Allen J D, Wilson R, Shanks R G
J Cardiovasc Pharmacol. 1982 Mar-Apr;4(2):221-5. doi: 10.1097/00005344-198203000-00009.
Alinidine (2.9 +/- 0.7 mg/kg) prevented an adrenaline-induced ventricular arrhythmia in dogs respired with halothane. In ouabain-induced ventricular tachycardia, a cumulative dose of alinidine (15.5 mg/kg) reduced the number of ventricular beats by 91.6 +/- 1.9%. The drug was much less effective in abolishing the ventricular tachycardia 24 h after ligation of a coronary artery, with only a 36 +/- 15% reduction in ventricular ectopic beats after 15.5 mg/kg. The administration of alinidine (0.5-1.0 mg/kg) to anaesthetized dogs with no cardiac arrhythmia reduced sinus node rate with little effect on the response of the node to vagal stimulation.
阿利尼定（2.9±0.7毫克/千克）可预防用氟烷通气的犬因肾上腺素诱发的室性心律失常。在哇巴因诱发的室性心动过速中，阿利尼定累积剂量（15.5毫克/千克）可使室性搏动次数减少91.6±1.9%。在冠状动脉结扎24小时后，该药物消除室性心动过速的效果要差得多，给予15.5毫克/千克后，室性早搏仅减少36±15%。给无心律失常的麻醉犬注射阿利尼定（0.5 - 1.0毫克/千克）可降低窦房结频率，而对窦房结对迷走神经刺激的反应影响很小。
