Starke K, Docherty J R
J Cardiovasc Pharmacol. 1982;4 Suppl 1:S3-7. doi: 10.1097/00005344-198200041-00002.
Both in the periphery and in the central nervous system, alpha-adrenoceptors can be subdivided into alpha 1-types. alpha 1-Receptors are sensitive to low concentrations of the agonists phenylephrine and methoxamine, and of the antagonists corynanthine and prazosin. alpha 1-Receptors are sensitive to low concentrations of the agonists clonidine and tramazoline, and of the antagonists yohimbine and rauwolscine. Although it has been shown recently that some smooth muscle tissues contain postsynaptic, contraction-mediating alpha 2-adrenoceptors, the smooth muscle of rabbit aorta and pulmonary artery possesses only alpha 1-receptors. In rabbit portal vein, practically all of the effect of exogenous agonists is mediated by alpha 1-receptors. On the other hand, prazosin resistance and rauwolscine sensitivity of the contractile response to transmural sympathetic nerve stimulation indicates that released noradrenaline may act on a small population of postsynaptic alpha 2-receptors as well.
在外周和中枢神经系统中，α-肾上腺素能受体均可细分为α1型。α1受体对低浓度的激动剂去氧肾上腺素和甲氧明以及拮抗剂育亨宾碱和哌唑嗪敏感。α1受体对低浓度的激动剂可乐定和曲马唑嗪以及拮抗剂育亨宾和萝芙木碱敏感。尽管最近已表明某些平滑肌组织含有突触后介导收缩的α2-肾上腺素能受体，但兔主动脉和肺动脉的平滑肌仅具有α1受体。在兔门静脉中，外源性激动剂的几乎所有作用均由α1受体介导。另一方面，对跨壁交感神经刺激的收缩反应具有哌唑嗪抗性和萝芙木碱敏感性，这表明释放的去甲肾上腺素也可能作用于一小部分突触后α2受体。
