Guellaen G, Aggerbeck M, Schmelck P, Barouki R, Hanoune J
J Cardiovasc Pharmacol. 1982;4 Suppl 1:S46-50. doi: 10.1097/00005344-198200041-00010.
Adrenergic receptors exist as two subtypes, alpha, and beta, in various tissues. In rat liver, catecholamines exert the same effect on glycogenolysis and neoglucogenesis via either alpha or beta control. In this review we report on the modification in the balance between alpha- and beta-adrenoreceptors induced as the result of adrenalectomy and extrahepatic cholestasis. Following adrenalectomy, the number of beta-adrenergic receptors in rat liver, measured using specific radioligands, increases two-fold, with no change in the alpha-adrenoreceptors. In extrahepatic cholestasis we measured a fourfold increase in the number of beta-sites and a two- to threefold decrease in the number of alpha-sites. Moreover, this modification in the balance between alpha- and beta-adrenoreceptors was concomitant with the apparition of a mixed beta- and alpha-adrenergic regulation of glycogenolysis in cholestatic rats, whereas this process is purely or almost purely alpha-adrenergic in normal rats.
肾上腺素能受体在各种组织中以两种亚型存在，即α型和β型。在大鼠肝脏中，儿茶酚胺通过α或β控制对糖原分解和糖异生发挥相同的作用。在本综述中，我们报告了肾上腺切除术和肝外胆汁淤积导致的α-和β-肾上腺素能受体平衡的改变。肾上腺切除术后，使用特异性放射性配体测量，大鼠肝脏中β-肾上腺素能受体的数量增加了两倍，而α-肾上腺素能受体数量没有变化。在肝外胆汁淤积中，我们测量到β位点数量增加了四倍，α位点数量减少了两到三倍。此外，α-和β-肾上腺素能受体平衡的这种改变与胆汁淤积大鼠糖原分解中混合的β-和α-肾上腺素能调节的出现同时发生，而在正常大鼠中这个过程纯粹或几乎纯粹是α-肾上腺素能的。
