Matsuno S, Miyashita E, Ejiri T, Sato T
Tohoku J Exp Med. 1982 Jan;136(1):11-22. doi: 10.1620/tjem.136.11.
Determinations were made of the Zn and Mg contents of pancreatic juice in 12 cases undergoing external pancreatic duct drainage following pancreaticoduodenectomy in order to investigate the output and excretion pattern of trace elements in pancreatic juice and also to study their relations to pancreatic enzyme secretion and fibrosis of the pancreas. THe results indicate that the output of Zn in pancreatic juice ran parallel with amylase activity and was closely related to secretion of pancreatic enzymes. Relatively smaller variations were noted of the Mg content in pancreatic juice during the postoperative course, with the pattern of Mg excretion in pancreatic juice being dependent upon the volume of pancreatic juice secreted. The output of both Zn and Mg in pancreatic juice correlated with the volume of the residual pancreatic parenchyma. The amylase/Zn concentration ratio of pancreatic juice remained stationary postoperatively in all cases and was shown to have a negative correlation with the pancreatic parenchymal ratio. The findings suggest that the amylase/Zn concentration ratio can be a reliable indication of the degree of pancreatic fibrosis or of pancreatic exocrine function.
为了研究胰液中微量元素的排出量和排泄模式，并探讨它们与胰酶分泌及胰腺纤维化的关系，对12例行胰十二指肠切除术后接受胰外引流的患者的胰液锌和镁含量进行了测定。结果表明，胰液中锌的排出量与淀粉酶活性平行，且与胰酶分泌密切相关。术后胰液中镁含量的变化相对较小，胰液中镁的排泄模式取决于胰液分泌量。胰液中锌和镁的排出量均与残余胰腺实质的体积相关。所有病例术后胰液淀粉酶/锌浓度比值保持稳定，且与胰腺实质比例呈负相关。这些发现提示，淀粉酶/锌浓度比值可作为胰腺纤维化程度或胰腺外分泌功能的可靠指标。
