Antigenic differences between normal human albumin and a genetic variant.

Agglutinating antisera were induced in rabbits against a purified genetic variant of human albumin and against normal albumin. These antisera had different specificities, as determined by inhibition experiments with the purified variant and normal albumin. The results suggest that genetic variants of human albumin differ antigenically from the normal protein. It is conceivable that antibodies against normal human albumin could be induced following albumin administration to individuals homozygous for an albumin variant.