Weed J C, Barnard D E, Currie J L, Clayton L A, Hammond C B
Obstet Gynecol. 1982 Mar;59(3):377-80.
The Southeastern Regional trophoblastic Disease Center has treated 126 patients with metastatic gestational trophoblastic disease from 1966 through 1979. Sixty-three cases were categorized as having a poor prognosis on the basis of criteria published previously. Since 1976, 18 patients have been treated with a modification of Bagshawe's multiagent chemotherapy protocol. Ten of 18 patients (56%) have achieved sustained remission. Seventy-eight percent of these patients encountered serious myelosuppression (white blood count 1000 cells or fewer) and 39% suffered severe thrombocytopenia (platelet count 50,000 or fewer). There were no deaths related to drug toxicity. The courses of therapy and complications of modified Bagshawe chemotherapy are reviewed.
1966年至1979年期间，东南部地区滋养细胞疾病中心共治疗了126例转移性妊娠滋养细胞疾病患者。根据此前公布的标准，其中63例被归类为预后不良。自1976年以来，18例患者接受了对巴格肖多药化疗方案的改良治疗。18例患者中有10例（56%）实现了持续缓解。这些患者中有78%出现了严重的骨髓抑制（白细胞计数为1000个细胞或更少），39%出现了严重的血小板减少症（血小板计数为50000个或更少）。没有与药物毒性相关的死亡病例。本文回顾了改良巴格肖化疗的治疗过程及并发症。
