口服芳香维甲酸（Ro 10-9359）治疗毛囊角化病：一项临床、光镜及电镜研究
Treatment of Darier's disease with an oral aromatic retinoid (Ro 10-9359): a clinical and light and electron microscopic study.
作者信息
Lauharanta J, Niemi K M, Lassus A
出版信息
Acta Derm Venereol. 1981;61(6):535-42.
An aromatic retinoid (Ro 10-9359) cleared 6 of 8 patients with Darier's disease in 4-6 weeks. After discontinuing the treatment, remission was maintained for up to 5 months. In 2 severe cases continuous treatment proved necessary in order to maintain the improved state. Acantholysis, various types of dyskeratosis and acanthosis with downward proliferation of rete ridges were seen by light microscopy before treatment. Electron microscopy revealed a decreased number of desmosomes and other cellular attachments and conspicuous microvillous changes of cell surface in separated basal cells. Keratinization in epidermal cells was premature and characterized by abnormal aggregations of keratinization products. Under the influence of retinoid there seemed to appear a new generation of basal cells better able to form intercellular attachments, after which the progress of keratinization in the entire epidermis shifted towards normal, and acanthosis decreased.
一种芳香维甲酸（Ro 10-9359）在4至6周内使8例 Darier病患者中的6例病情得到缓解。停止治疗后，缓解状态维持了长达5个月。在2例严重病例中，为了维持改善状态，持续治疗被证明是必要的。治疗前通过光学显微镜观察到棘层松解、各种类型的角化不良以及伴有 rete 嵴向下增生的棘皮症。电子显微镜显示桥粒和其他细胞连接数量减少，分离的基底细胞中细胞表面有明显的微绒毛变化。表皮细胞的角化过早，其特征是角化产物异常聚集。在维甲酸的影响下，似乎出现了新一代能够更好地形成细胞间连接的基底细胞，此后整个表皮的角化进程转向正常，棘皮症减轻。
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