卡巴胆碱增强了猫下颌下腺中血管活性肠肽对环磷酸腺苷的刺激作用。
Carbachol potentiates the cyclic AMP-stimulating effect of VIP in cat submandibular gland.
作者信息
Enyedi P, Fredholm B B, Lundberg J M, Anggård A
出版信息
Eur J Pharmacol. 1982 Apr 8;79(1-2):139-43. doi: 10.1016/0014-2999(82)90586-6.
The effect of VIP and carbachol on cyclic AMP production were studied in isolated acini of the cat submandibular gland and guinea pig pancreas. VIP was almost 100 times more potent in stimulating cyclic AMP in the pancreas than in the submandibular salivary gland. Carbachol did not influence cyclic AMP in the pancreas while a 20-30% increase was seen in the submandibular gland. The addition of carbachol potentiated the cyclic AMP response to VIP in the submandibular acini while no such effect was observed in the pancreas. Atropine abolished the effect of carbachol.
在猫下颌下腺和豚鼠胰腺的分离腺泡中研究了血管活性肠肽（VIP）和卡巴胆碱对环磷酸腺苷（cAMP）生成的影响。VIP刺激胰腺中cAMP生成的效力几乎是刺激下颌下唾液腺的100倍。卡巴胆碱对胰腺中的cAMP没有影响，而在下颌下腺中可观察到cAMP增加20 - 30%。在颌下腺泡中，加入卡巴胆碱可增强对VIP的cAMP反应，而在胰腺中未观察到这种效应。阿托品可消除卡巴胆碱的作用。
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