Vadeboncoeur C, Proulx M, Trahan L
J Dent Res. 1982 May;61(5):632-5. doi: 10.1177/00220345820610050201.
The effect of gramicidin D, Gramicidin S, and carbonylcyanide p-trifluoromethoxyphenyl hydrazone on the glycolysis of various oral streptococci was investigated. Gramicidin D was the most effective and inhibited the glycolysis of all the streptococci studied in the presence of the most common sugars found in man's diet (sucrose, lactose, glucose, and fructose). A concentration of 2.5 X 10(-6) M gramicidin D was sufficient to decrease significantly the rate of glycolysis of human dental plaque in the presence of sucrose. The use of this ionophore as a caries preventive agent is discussed.
研究了短杆菌肽D、短杆菌肽S和羰基氰对-三氟甲氧基苯腙对各种口腔链球菌糖酵解的影响。短杆菌肽D最有效，在人类饮食中最常见的糖类（蔗糖、乳糖、葡萄糖和果糖）存在的情况下，它能抑制所有所研究链球菌的糖酵解。在有蔗糖存在的情况下，2.5×10⁻⁶ M的短杆菌肽D浓度足以显著降低人牙菌斑的糖酵解速率。本文讨论了将这种离子载体用作防龋剂的问题。
