Smith R N, Margolias R T, Sternlicht M
J Immunol. 1982 Aug;129(2):777-82.
We compared the cross-reactive pattern of alloantibodies from conventional anti-DA alloimmunizations with anti-RT1Aa alloantibodies brought about by secondary and primary pregnancy-induced alloimmunizations caused by pregnancies by DA males. As expected, conventional alloimmunization produces alloantibodies that are cross-reactive; secondary pregnancy-induced anti-RT1Aa alloantibodies induced by pregnancies by DA males in females previously immunized against DA were as cross-reactive as conventionally raised antibodies. But primary pregnancy-induced anti-RI1Aa alloantibodies brought about by DA pregnancies in unimmunized females were not as cross-reactive as alloantibodies from conventional or secondary pregnancy-induced alloimmunizations. The cross-reactive pattern of the alloantibodies from primary pregnancy-induced alloimmunizations was distinctive for each of the three responding strains, but the cross-reactive pattern observed for a particular strain was not uniformly seen in all the responding females of that strain. One such pattern between two congenic strains defines an Ir gene between two RT1 phenotypes that are known to be high responders to RT1Aa.
我们比较了传统抗DA同种免疫产生的同种抗体的交叉反应模式，以及由DA雄性导致的初次和二次妊娠诱导的同种免疫所产生的抗RT1Aa同种抗体的交叉反应模式。正如预期的那样，传统的同种免疫产生具有交叉反应性的同种抗体；在先前针对DA免疫的雌性中，由DA雄性导致的妊娠所诱导的二次妊娠诱导抗RT1Aa同种抗体与传统产生的抗体一样具有交叉反应性。但是，未免疫雌性中由DA妊娠导致的初次妊娠诱导抗RI1Aa同种抗体的交叉反应性不如传统或二次妊娠诱导的同种免疫产生的同种抗体。初次妊娠诱导的同种免疫产生的同种抗体的交叉反应模式在三个应答品系中各有特点，但在该品系的所有应答雌性中，特定品系观察到的交叉反应模式并不一致。两个同源品系之间的一种这样的模式定义了两个已知对RT1Aa高应答的RT1表型之间的一个Ir基因。
