Risberg B, Miller E, Hughes J
Acta Chir Scand. 1981;147(8):613-8.
The cardio-pulmonary effects of a rapid infusion of a crystalloid (Ringer's lactate) and a colloid solution (Dextran 40) were compared in healthy dogs. The colloid solution produced a long lasting volume expansion and hemodilution. The improved circulation in this group was reflected in an increased cardiac output and arterial blood pressure. The ventilation/perfusion ratios were reduced and the pulmonary vascular resistance was significantly lower in the colloid group in comparison both to the crystalloid group as well as to the control animals. The total oxygen consumption increased slightly in the colloid group but decreased in the crystalloid group. The postmortem extravascular lung water content did not differ in the groups.
在健康犬中比较了快速输注晶体液（乳酸林格氏液）和胶体溶液（右旋糖酐40）对心肺的影响。胶体溶液产生持久的容量扩张和血液稀释。该组循环改善表现为心输出量增加和动脉血压升高。与晶体液组和对照组动物相比，胶体组的通气/灌注比降低，肺血管阻力显著降低。胶体组的总氧耗量略有增加，而晶体液组则降低。各组的尸检血管外肺含水量无差异。
