母血清甲胎蛋白筛查对产前诊断的影响。
Impact of maternal serum alpha-fetoprotein screening on antenatal diagnosis.
作者信息
Brock D J
出版信息
Br Med J (Clin Res Ed). 1982 Jul 31;285(6338):365-7. doi: 10.1136/bmj.285.6338.365.
An analysis has been made of indications for amniocentesis in the Edinburgh area from 1979 to 1981. About 5% of all mothers underwent the procedure. Among 2137 amniocenteses, 37% were performed on mothers 35 years old or more, and 30% on patients with raised serum alpha-fetoprotein. The total number of amniocenteses and the categories have been stable for the past three years. As a result of amniocentesis 104 pregnancies were terminated, 66 of which (63%) followed a raised maternal serum alpha-fetoprotein indication, while only 10 (9.6%) were in mothers aged 35 or more. There were a further 12 terminations based on raised serum alpha-fetoprotein but where no amniocentesis had been thought necessary. Even when figures for anencephaly are excluded from the analysis, maternal serum alpha-fetoprotein screening was responsible for detecting 35 out of 63 (56%) abnormal fetuses. This constitutes a strong case for the continuation of alpha-fetoprotein screening programmes.
对1979年至1981年爱丁堡地区羊膜穿刺术的指征进行了分析。所有产妇中约5%接受了该手术。在2137例羊膜穿刺术中，37%是为35岁及以上的产妇进行的，30%是为血清甲胎蛋白升高的患者进行的。在过去三年中，羊膜穿刺术的总数和类别一直保持稳定。羊膜穿刺术导致104例妊娠终止，其中66例（63%）是基于母亲血清甲胎蛋白升高的指征，而只有10例（9.6%）是35岁及以上的母亲。另外还有12例基于血清甲胎蛋白升高但认为无需进行羊膜穿刺术的终止妊娠。即使在分析中排除无脑儿的数据，母亲血清甲胎蛋白筛查仍检测出63例异常胎儿中的35例（56%）。这有力地支持了继续开展甲胎蛋白筛查项目。
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