Maccario M, Hefferen S J, Keblusek S J, Lipinski K A
Dev Med Child Neurol. 1982 Apr;24(2):141-55. doi: 10.1111/j.1469-8749.1982.tb08793.x.
Seven patients, six boys and one girl, ranging in age from 2 years 7 months to 5 years 6 months at first contact, presented with severe language delay and dysphasic errors. They were found to have markedly abnormal EEGs despite the fact that only two of the children had had febrile seizures. The EEG abnormalities consisted to spike-wave or sharp wave discharges in focal or bilateral synchronous fashion, and were not affected by anticonvulsants. The children had normal motor development and no dysmorphic features. Results of neurological examinations were normal. CT and isotope scans were unrevealing. Intelligence, measured by a non-verbal scale, was normal. The authors suggest that an electrophysiological disturbance was the underlying cause of both the language deficits and the EEG abnormalities. The remarkably frequent occurrence of postmaturity (five of the seven cases) suggests that perinatal events may be an etiological factor.
7名患者，6名男孩和1名女孩，首次就诊时年龄在2岁7个月至5岁6个月之间，表现为严重的语言发育迟缓及言语障碍性错误。尽管这些儿童中只有2人曾有高热惊厥，但他们的脑电图（EEG）显示明显异常。EEG异常表现为局灶性或双侧同步的尖波或锐波放电，且不受抗惊厥药物影响。这些儿童运动发育正常，无畸形特征。神经系统检查结果正常。CT和同位素扫描未发现异常。通过非语言量表测量的智力正常。作者认为，电生理紊乱是语言缺陷和EEG异常的潜在原因。过期产的发生率极高（7例中有5例），提示围产期事件可能是一个病因。
