Lakkad B C, Nigam S K, Karnik A B, Thakore K N, Aravinda Babu K, Bhatt D K, Kashyap S K
Mutat Res. 1982 Jun;101(4):315-20. doi: 10.1016/0165-1218(82)90124-0.
Male Swiss mice, 6-8 weeks old, were given a diet containing technical-grade hexachlorocyclohexane (BHC) at 500 ppm continuously for 4, 6 and 8 months. After the completion of the scheduled exposure period, the males were sequentially mated with 2-3 untreated virgin females at weekly intervals for 8 weeks. The females were autopsied at mid-term pregnancy for evaluation of dominant-lethal mutation. The number of dead implants, including deciduomas and dead embryos, showed a significant increase. Similarly, the percentage fertility and live embryos per female showed a decline when compared with the control
