Hughes A S, Ilsley C D, Wilkinson L
Thromb Res. 1982 Jun 15;26(6):425-30. doi: 10.1016/0049-3848(82)90314-0.
Twenty-six normal subjects (aged 18-52) and eighteen patients with ischaemic heart disease (aged 36-67) underwent maximal 12 lead ECG treadmill exercise testing. Coronary angiography was performed on sixteen of the patients. In-vivo platelet activation was assessed by measuring plasma levels of the platelet specific protein beta-thromboglobulin (beta-tg). The mean beta-tg levels pre- and post-exercise in the normal subjects were 47 (SD: 42- 26-85) ng/ml and 48 (29-78) ng/ml respectively, and in the patient group 68 (43-107) ng/ml and 70 (45-109) ng/ml. There was a significant difference between the two groups at rest (p less than 0.05), but there was no change in either following exercise. Post exercise beta-tg levels showed no correlation with the degree of induced ischaemia as judged by ST segment depression and the number of leads involved. Resting beta-tg levels, however, were positively correlated with the presence and extent of angiographically demonstrable coronary disease (r = 0.53, p less than 0.05). We conclude that in vivo platelet activation is present at rest in patients with coronary artery disease, and whilst related to the presence and extent of such disease is unrelated to induced ischaemia.
26名正常受试者（年龄18 - 52岁）和18名缺血性心脏病患者（年龄36 - 67岁）接受了12导联心电图平板运动试验。对其中16名患者进行了冠状动脉造影。通过测量血小板特异性蛋白β-血小板球蛋白（β-tg）的血浆水平来评估体内血小板活化情况。正常受试者运动前和运动后的平均β-tg水平分别为47（标准差：42 - 26 - 85）ng/ml和48（29 - 78）ng/ml，患者组分别为68（43 - 107）ng/ml和70（45 - 109）ng/ml。两组在静息状态下有显著差异（p < 0.05），但运动后两组均无变化。运动后β-tg水平与根据ST段压低和受累导联数判断的诱发缺血程度无关。然而，静息β-tg水平与冠状动脉造影显示的冠心病的存在和程度呈正相关（r = 0.53，p < 0.05）。我们得出结论，冠心病患者在静息状态下存在体内血小板活化，并且虽然与这种疾病的存在和程度相关，但与诱发缺血无关。
