两种克雅氏病中的脑单胺异常。

Brain monoamine abnormalities in the two types of Creutzfeldt-Jakob disease.

作者信息

Nyberg P, Almay B G, Carlsson A, Masters C, Winblad B

出版信息

Acta Neurol Scand. 1982 Jul;66(1):16-24. doi: 10.1111/j.1600-0404.1982.tb03125.x.

DOI:10.1111/j.1600-0404.1982.tb03125.x

Abstract

Analysis of monoamine concentrations in brain tissue was carried out on the two types of Creutzfeldt-Jakob disease (CJD). The results showed decreased levels of catecholamines compared to control cases in a number of areas, and the reductions were most pronounced for dopamine. In general, the case classified as the amyotrophic form of CJD showed a greater degree of a monoamine loss than the case with spongiform encephalopathy, which is the typical transmissible form of CJD. These findings support the scarce available data indicating disturbances in the catecholaminergic systems in these types of brain diseases, and may have therapeutic implications.

摘要

对两种克雅氏病（CJD）的脑组织单胺浓度进行了分析。结果显示，与对照病例相比，多个区域的儿茶酚胺水平降低，其中多巴胺的降低最为明显。一般来说，被归类为肌萎缩型克雅氏病的病例比具有海绵状脑病（克雅氏病的典型传播形式）的病例单胺损失程度更大。这些发现支持了现有的稀缺数据，表明这些类型的脑部疾病中儿茶酚胺能系统存在紊乱，并且可能具有治疗意义。