Epstein W L, Byers V S, Frankart W
Arch Dermatol. 1982 Sep;118(9):630-3.
Twenty-one adults, highly sensitive to urushiol, the allergen in poison oak/ivy, ingested up to 300 mg of urushiol over three to six months. A control group received placebo capsules. The study was done double blind to evaluate changes in patch test reactivity to urushiol, altered reactivity to an unrelated contract sensitizer, side effects, and duration of hyposensitization. A significant number of subjects in the experimental group (15/21) became hyposensitized. Such hyposensitization was not seen in the control group (2/12), and the difference between groups was significant. No change in reactivity to an unrelated contact sensitizer occurred in subjects hyposensitized to urushiol, suggesting antigen specificity. Retesting up to three months after completion of the protocol indicated that subjects remained hyposensitized without a "rebound" effect during the time. Side effects, detected by questionnaire, were limited to vesicular and urticarial rashes and pruritus ani in 18 of 21 test subjects.
21名对毒栎/毒漆树中的过敏原漆酚高度敏感的成年人，在三到六个月内摄入了高达300毫克的漆酚。一个对照组服用安慰剂胶囊。该研究采用双盲法进行，以评估对漆酚的斑贴试验反应性变化、对无关接触致敏剂的反应性改变、副作用以及脱敏持续时间。实验组中有相当数量的受试者（15/21）出现了脱敏现象。对照组（2/12）未出现这种脱敏现象，两组之间的差异具有显著性。对漆酚脱敏的受试者对无关接触致敏剂的反应性没有变化，表明具有抗原特异性。在方案完成后长达三个月的重新测试表明，受试者在此期间仍保持脱敏状态，没有“反弹”效应。通过问卷调查检测到的副作用仅限于21名受试对象中的18人出现水疱性和荨麻疹性皮疹以及肛门瘙痒。
