Henze E, Schelbert H R, Collins J D, Najafi A, Barrio J R, Bennett L R
J Nucl Med. 1982 Oct;23(10):923-9.
Current agents for lymphoscintigraphy have limitations because of slow migration of the colloidal tracers from the injection site and the unknown effect of phagocytosis on the removal of the labeled particles. The usefulness of Tc-99m dextran (TcDx) with a molecular weight of 110,000 has been tested for lymphoscintigraphy. Computer-assisted dynamic imaging and serial blood sampling in 13 dog experiments demonstrated that the tracer cleared only by lymph drainage from an interstitial injection site. Following interdigital injection of 1.0 ml (0.5-5.0 mCi), TcDx reached the knee or elbow lymph nodes in 12.4 +/- 6.5 (1 s.d.) sec, and the inguinal or axillary lymph nodes in 98.0 +/- 42.3 sec. It cleared from the injection site with a half-time of 31.5 min. In a dog with surgically induced lymphedema, tracer migration was markedly delayed in the edematous leg and the radionuclide lymphoscintigram resembled the contrast lymphangiogram. Initial studies in man yielded high-quality radionuclide lymphograms of the leg, and the pelvic and paraaortic lymph nodes. We conclude that TcDx is very promising for lymphoscintigraphy.
目前用于淋巴闪烁造影的试剂存在局限性，这是因为胶体示踪剂从注射部位迁移缓慢，以及吞噬作用对标记颗粒清除的影响尚不清楚。已对分子量为110,000的锝-99m葡聚糖（TcDx）用于淋巴闪烁造影的效用进行了测试。在13项犬实验中进行的计算机辅助动态成像和连续血液采样表明，示踪剂仅通过从间质注射部位的淋巴引流而清除。在指间注射1.0 ml（0.5 - 5.0 mCi）后，TcDx在12.4 +/- 6.5（1个标准差）秒内到达膝部或肘部淋巴结，在98.0 +/- 42.3秒内到达腹股沟或腋窝淋巴结。它从注射部位清除的半衰期为31.5分钟。在一只手术诱导淋巴水肿的犬中，示踪剂在水肿腿部的迁移明显延迟，放射性核素淋巴闪烁造影类似于造影淋巴管造影。在人体进行的初步研究获得了高质量的腿部、盆腔和腹主动脉旁淋巴结的放射性核素淋巴造影。我们得出结论，TcDx在淋巴闪烁造影方面非常有前景。
