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[+Gx加速度和阿德托隆对小鼠外周血核酸含量及其他指标的影响]

[Effect of +Gx acceleration and adeturon on the nucleic acid content and other indices of the peripheral blood of mice].

作者信息

Minkova M I, Nikolov I T, Datsov E R, Pantev T P, Tenchova V B

出版信息

Kosm Biol Aviakosm Med. 1982 Jul-Aug;16(4):58-60.

PMID:6181293
Abstract

The effect of acceleration and adeturon, a radioprotector, on the content of nucleic acids, the count, composition and osmotic resistance of white and red blood cells was investigated. Male mice of the H strain were exposed to +20 Gx for 5 min. The above parameters were measured 1, 24 and 48 hrs after the exposure. The nucleic acid content decreased significantly immediately after the exposure and tended to return to normal afterwards. The leucocyte count was increased during all observation periods, and the erythrocyte count was decreased 1 hr after the exposure. Osmotic resistance of white and red blood cells varied in a different manner after the exposure. Adeturon administered at optimal protective doses (300 mg/kg) modified regulatory mechanisms of the animal body.

摘要

研究了加速度以及辐射防护剂阿地托龙对核酸含量、白细胞和红细胞的数量、组成及渗透抵抗力的影响。选用H品系雄性小鼠,使其暴露于+20 Gx环境下5分钟。在暴露后1小时、24小时和48小时测量上述参数。暴露后核酸含量立即显著下降,之后有恢复正常的趋势。在所有观察期内白细胞数量均增加,暴露后1小时红细胞数量减少。暴露后白细胞和红细胞的渗透抵抗力变化方式不同。以最佳防护剂量(300毫克/千克)给予阿地托龙可改变动物机体的调节机制。

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