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P物质的神经解剖学定位：对中枢心血管控制的影响

Neuroanatomical localization of substance p: implications for central cardiovascular control.

作者信息

Helke C J

出版信息

Peptides. 1982 May-Jun;3(3):479-83. doi: 10.1016/0196-9781(82)90111-5.

DOI:10.1016/0196-9781(82)90111-5
PMID:6181493
Abstract

The presence of substance P (SP) neurons in pathways known to be involved in the central control of the cardiovascular system has been studied with neuroanatomical and neurochemical techniques. SP-immunoreactive (SP-I) neurons are found in afferent baro- and chemoreceptor pathways which transmit information from peripheral receptors to the nucleus tractus solitarius. In addition, SP-I neurons located in the nucleus interfascicularis hypoglossi of the ventral medulla innervate the intermediolateral cell column, the site of origin of preganglionic sympthetic nerves. The role of these SP-I neurons in cardiovascular control remains to be determined.

摘要

运用神经解剖学和神经化学技术，对已知参与心血管系统中枢控制的通路中P物质（SP）神经元的存在情况进行了研究。在传入的压力感受器和化学感受器通路中发现了SP免疫反应性（SP-I）神经元，这些通路将信息从外周感受器传递至孤束核。此外，位于延髓腹侧舌下神经束间核的SP-I神经元支配中间外侧细胞柱，即节前交感神经的起源部位。这些SP-I神经元在心血管控制中的作用仍有待确定。

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Neuroanatomical localization of substance p: implications for central cardiovascular control.P物质的神经解剖学定位：对中枢心血管控制的影响
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引用本文的文献

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The Role of Substance P in Secondary Pathophysiology after Traumatic Brain Injury.P物质在创伤性脑损伤后继发性病理生理学中的作用
Front Neurol. 2017 Jun 28;8:304. doi: 10.3389/fneur.2017.00304. eCollection 2017.
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Distribution of vasoactive intestinal polypeptide-like immunoreactivity in the mammalian heart. Interrelation with neurotensin- and substance P-like immunoreactive nerves.血管活性肠肽样免疫反应性物质在哺乳动物心脏中的分布。与神经降压素样和P物质样免疫反应性神经的相互关系。
Cell Tissue Res. 1984;236(3):527-40. doi: 10.1007/BF00217219.
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Neurotensin and substance P immunoreactive nerve endings in the guinea pig carotid sinus and their ultrastructural counterparts.
豚鼠颈动脉窦中神经降压素和P物质免疫反应性神经末梢及其超微结构对应物。
Anat Embryol (Berl). 1983;167(3):347-54. doi: 10.1007/BF00315672.
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Evidence for a capsaicin-sensitive vasomotor mechanism in the ventral medullary chemosensitive area of the cat.猫延髓腹侧化学敏感区中辣椒素敏感的血管运动机制的证据。
Naunyn Schmiedebergs Arch Pharmacol. 1985 Mar;329(1):56-62. doi: 10.1007/BF00695193.
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Distribution of calcitonin gene-related peptide-like immunoreactivity in the guinea pig heart.
Anat Embryol (Berl). 1986;175(2):255-60. doi: 10.1007/BF00389603.
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Substance P-immunoreactive neurons in the brainstem of the cat related to cardiovascular centers.
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