Galabov A S, Mastikova M
Acta Virol. 1982 May;26(3):137-47.
2,6-Bis(diethanolamino)-4,8-dipiperidinopyrimido-[5,4-d]-pyrimidine (dipyridamole) induced interferon production in vitro in explanted mouse peritoneal leukocytes and to a lower degree in non-lymphoidal cell cultures of mouse (L cells primary embryo fibroblasts) and human (diploid embryo lung fibroblasts) origin. Dipyridamole induced interferon also in mice after intravenous administration. Peak interferon levels in the blood (128 IU/ml) were attained at 49 hr after injection of 0.1 mg dipyridamole per kg body weight and at 24 and 12 hr after injection of 0.6-1.8 and 16.7 mg/kg respectively. By its pH stability, thermostability and antigenic properties the interferon induced in mice, mouse peritoneal leukocytes and L cells corresponded to IFN-alpha and IFN-beta. This interferon-inducing capacity of dipyridamole may account for its broad-spectrum antiviral effect.
2,6-双（二乙醇氨基）-4,8-二哌啶基嘧啶并-[5,4-d]-嘧啶（双嘧达莫）在体外可诱导外植的小鼠腹腔白细胞产生干扰素，在源自小鼠（L细胞、原代胚胎成纤维细胞）和人（二倍体胚胎肺成纤维细胞）的非淋巴细胞培养物中诱导能力稍弱。静脉注射双嘧达莫后，小鼠体内也可诱导产生干扰素。每千克体重注射0.1毫克双嘧达莫后49小时，以及分别注射0.6 - 1.8毫克/千克和16.7毫克/千克后24小时和12小时，血液中干扰素水平达到峰值（128国际单位/毫升）。从小鼠、小鼠腹腔白细胞和L细胞中诱导产生的干扰素，其pH稳定性、热稳定性和抗原特性与Ⅰ型干扰素（IFN-α和IFN-β）相符。双嘧达莫的这种干扰素诱导能力可能解释了其广谱抗病毒作用。
