双嘧达莫可在人体内诱导产生干扰素。
Dipyridamole induces interferon in man.
作者信息
Galabov A S, Mastikova M
出版信息
Biomed Pharmacother. 1984;38(8):412-3.
PMID:6084526
Abstract
Thirty-six out of 40 healthy volunteers responded with a markedly elevated blood interferon (IFN) content to a single oral administration of dipyridamole (a 100 mg dose): 958.0 +/- 23.5 IU/ml serum at the 24th-48th hour. A hyporeactivity state to the repeated inducer application was found within the time interval of 4th-6th day. It was established that 7/8 of the dipyridamole-induced IFN represented IFN-alpha.
摘要
40名健康志愿者中，有36人在单次口服双嘧达莫（100毫克剂量）后，血液干扰素（IFN）含量显著升高：在第24至48小时时血清中为958.0 +/- 23.5国际单位/毫升。在第4至6天的时间间隔内发现对重复诱导剂应用存在低反应性状态。已确定双嘧达莫诱导的IFN中7/8为IFN-α。
Zotero 插件