Sawada M, Oshikane M, Matsui Y, Okudaira Y, Kawashima M, Iwanaga K
Nihon Sanka Fujinka Gakkai Zasshi. 1982 Sep;34(9):1559-65.
The effects of human interferon on the growth of xenografted human tumors were studied. Human lymphoblastoid interferon (IFN) was administered intraperitoneally to nude mice with yolk sac tumors of the ovary (YST-1 and YST-2) and endometrial carcinoma (AD-19). IFN inhibited the growth of YST-1 tumor at a dose of 1.0 X 10(6)u/kg/day for twenty one days, and AD-19 tumor at a dose of 1.0 X 10(6)u/kg/day for twenty eight days. On the other hand, IFN failed to inhibit the growth of YST-2 tumor at a dose of 1.0 X 10(6)u/kg/day for eight days. The coefficient of correlation between tumor volume and serum alpha-fetoprotein of tumor-bearing mice was 0.51 in YST-1 and 0.42 in YST-2. No morphologic difference was observed between tumor cells from IFN-treated mice and control tumor-bearing mice. No severe weight loss of tumor-bearing mice was recognized after treatment with IFN. From these results, the usefulness of IFN for clinical treatment was suggested.
研究了人干扰素对异种移植的人肿瘤生长的影响。将人淋巴母细胞干扰素（IFN）腹腔注射给患有卵巢卵黄囊瘤（YST - 1和YST - 2）和子宫内膜癌（AD - 19）的裸鼠。IFN以1.0×10⁶单位/千克/天的剂量连续给药21天可抑制YST - 1肿瘤的生长，以1.0×10⁶单位/千克/天的剂量连续给药28天可抑制AD - 19肿瘤的生长。另一方面，IFN以1.0×10⁶单位/千克/天的剂量给药8天未能抑制YST - 2肿瘤的生长。荷瘤小鼠肿瘤体积与血清甲胎蛋白之间的相关系数在YST - 1中为0.51，在YST - 2中为0.42。在接受IFN治疗的小鼠的肿瘤细胞与对照荷瘤小鼠的肿瘤细胞之间未观察到形态学差异。荷瘤小鼠在接受IFN治疗后未出现严重体重减轻。从这些结果来看，提示了IFN在临床治疗中的有效性。
