Naim M, Brand J G, Kare M R
J Nutr. 1982 Nov;112(11):2104-15. doi: 10.1093/jn/112.11.2104.
Growing rats were fed either 10 to 17% protein (casein) diets whose taste was changed daily by addition of aversive stimuli. Under these circumstances food intake and body weight gain were reduced compared with controls fed unadulterated diets. More amylolytic activity per gram pancreas was found in rats fed a 10% protein, aversive diet and in their pair-fed controls fed restricted amounts of an unadulterated diet compared with ad libitum controls. More amylolytic activity per gram chyme of small intestine was also found in rats fed less than ad libitum amounts of a 10% protein diet. The chymotrypsin activity in the pancreas of rats fed a 17% protein, aversive diet was greater than in that of control animals or that of the pair-fed animals. The 2- to 10-fold higher proteolytic activity found in the small intestine and especially in the large intestine and feces of rats fed the aversive diet was specifically related to the adulteration of the diet with sodium saccharin. Feeding a diet containing sodium saccharin led to lower cecal pH. Under conditions of the present experiments, changes in digestive enzyme activity are not directly related to the aversive taste of the diet.
给生长中的大鼠喂食蛋白质含量为10%至17%（酪蛋白）的日粮，其味道每天通过添加厌恶刺激物而改变。在这种情况下，与喂食未掺假日粮的对照组相比，食物摄入量和体重增加量均减少。与自由采食对照组相比，喂食10%蛋白质厌恶日粮的大鼠及其按配对喂食限制量未掺假日粮的对照组大鼠，每克胰腺的淀粉酶活性更高。喂食少于自由采食量的10%蛋白质日粮的大鼠，每克小肠食糜的淀粉酶活性也更高。喂食17%蛋白质厌恶日粮的大鼠胰腺中的胰凝乳蛋白酶活性高于对照动物或配对喂食动物。在喂食厌恶日粮的大鼠的小肠中，尤其是大肠和粪便中发现的蛋白水解活性高2至10倍，这与日粮中添加糖精钠的掺假有关。喂食含糖精钠的日粮会导致盲肠pH值降低。在本实验条件下，消化酶活性的变化与日粮的厌恶味道没有直接关系。
