Mikami H, Ogihara T, Ohde H, Naka T, Kumahara Y
Jpn Circ J. 1982 Nov;46(11):1154-8. doi: 10.1253/jcj.46.1154.
In spontaneoulsy hypertensive rats (SHR), the hypotensive effect of captopril (30 mg/kg/day per os for 4 days), which inhibits the converting enzyme when given orally was significantly potentiated rather than suppressed by aprotonin (100,000 KIU/day s.c. for 7 days), but was not affected by indomethacin. These findings suggest that neither the kallikrein-kinin system nor the prostaglandin system is involved in any of the hypotensive actions of captopril in SHR other than the inhibition of the converting enzyme.
在自发性高血压大鼠（SHR）中，卡托普利（口服30毫克/千克/天，共4天）的降压作用在口服时可抑制转化酶，而抑肽酶（皮下注射100,000国际单位/天，共7天）可显著增强而非抑制其降压作用，但吲哚美辛对其无影响。这些发现表明，除了抑制转化酶外，激肽释放酶-激肽系统和前列腺素系统均未参与卡托普利在SHR中的任何降压作用。
