Holzer P, Bucsics A, Lembeck F
Neurosci Lett. 1982 Aug 31;31(3):253-7. doi: 10.1016/0304-3940(82)90029-5.
Treatment of newborn rats with capsaicin causes a selective and permanent degeneration of unmyelinated sensory fibres, some of which contain immunoreactive substance P (ISP). Following treatment of newborn rats with capsaicin (50 mg/kg), the ISP content was decreased by 66-75% in various skin areas and in the oral and nasal mucosae as measured at the age of 3-4 months. There was no significant depletion of ISP in the mucosa of the tongue. The ISP content of trachea, lungs, myocardium, hepatic duct, ureter and urinary bladder, was decreased by 60-84%. The ISP concentrations in stellate and mesenteric ganglia were reduced by 54 and 81%, respectively. These results indicate a widespread innervation of cutaneous and visceral tissues by sensory nerve fibers containing ISP.
用辣椒素处理新生大鼠会导致无髓鞘感觉纤维发生选择性和永久性退化，其中一些纤维含有免疫反应性P物质（ISP）。在用辣椒素（50mg/kg）处理新生大鼠后，在3 - 4月龄时测量发现，不同皮肤区域以及口腔和鼻腔黏膜中的ISP含量降低了66 - 75%。舌黏膜中的ISP没有明显减少。气管、肺、心肌、肝管、输尿管和膀胱中的ISP含量降低了60 - 84%。星状神经节和肠系膜神经节中的ISP浓度分别降低了54%和81%。这些结果表明，含有ISP的感觉神经纤维广泛支配皮肤和内脏组织。
