博来霉素A2的DNA结合部分类似物——3-（2'-苯基-2,4'-联噻唑-4-甲酰胺基）丙基二甲基碘化硫鎓的X射线晶体学分析
X-ray crystallographic analysis of 3-(2'-phenyl-2,4'-bithiazole-4-carboxamido) propyldimethylsulphonium iodide, an analogue of the DNA-binding portion of bleomycin A2.
作者信息
Kuroda R, Neidle S, Riordan J M, Sakai T T
出版信息
Nucleic Acids Res. 1982 Aug 11;10(15):4753-63. doi: 10.1093/nar/10.15.4753.
Abstract
The crystal and molecular structure of the title compound, an analogue of the DNA binding region of bleomycin A2, has been determined by X-ray crystallography. All the three independent molecules in an asymmetric unit are approximately planar with fully extended side chains. A computer graphics model-building study has shown that the phenyl group and the second thiazole ring can be intercalated between the base pairs of the double-stranded deoxydinucleoside phosphate d(CpG), and also that the sulphonium cation can interact with a backbone phosphate group. This model is in accord with NMR spectral data.
摘要
通过X射线晶体学确定了标题化合物（博来霉素A2的DNA结合区域类似物）的晶体和分子结构。不对称单元中的所有三个独立分子均近似平面结构，侧链完全伸展。计算机图形模型构建研究表明，苯基和第二个噻唑环可插入双链脱氧二核苷磷酸d(CpG)的碱基对之间，并且锍阳离子可与主链磷酸基团相互作用。该模型与核磁共振光谱数据一致。
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X-ray crystallographic analysis of 3-(2'-phenyl-2,4'-bithiazole-4-carboxamido) propyldimethylsulphonium iodide, an analogue of the DNA-binding portion of bleomycin A2.博来霉素A2的DNA结合部分类似物——3-（2'-苯基-2,4'-联噻唑-4-甲酰胺基）丙基二甲基碘化硫鎓的X射线晶体学分析
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Copper(II).bleomycin, iron(III).bleomycin, and copper(II).phleomycin: comparative study of deoxyribonucleic acid binding.铜（II）.博来霉素、铁（III）.博来霉素和铜（II）.平阳霉素：脱氧核糖核酸结合的比较研究
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