Wellinger K, Koltai M
Acta Physiol Acad Sci Hung. 1981;58(4):317-9.
The dextran-induced anaphylactoid reaction in the rat is susceptible to changes in carbohydrate metabolism. Paw oedema evoked by dextran was studied in norma and streptozotocin diabetic rats whose blood sugar level was determined by the glucose oxidase method. Insulin and tolbutamide increased dextran oedema in normal animals, while butylbiguanide (BBG) did not. The marked inhibition observed in the diabetic state was reversed by insulin and BBG, but not by tolbutamide. The dextran response correlated with the blood sugar level. These results suggest that the weak response to dextran in diabetic rats is due to an impaired peripheral glucose utilization rather than insulin deficiency per se.
大鼠中右旋糖酐诱导的类过敏反应易受碳水化合物代谢变化的影响。通过葡萄糖氧化酶法测定血糖水平，研究了正常大鼠和链脲佐菌素诱导的糖尿病大鼠中右旋糖酐诱发的爪部水肿。胰岛素和甲苯磺丁脲可增加正常动物的右旋糖酐水肿，而丁双胍（BBG）则无此作用。糖尿病状态下观察到的显著抑制作用可被胰岛素和BBG逆转，但不能被甲苯磺丁脲逆转。右旋糖酐反应与血糖水平相关。这些结果表明，糖尿病大鼠对右旋糖酐的反应较弱是由于外周葡萄糖利用受损，而非胰岛素本身缺乏。
