Costa M, Furness J B, Franco R, Llewellyn-Smith I, Murphy R, Beardsley A M
Ciba Found Symp. 1982(91):129-44. doi: 10.1002/9780470720738.ch8.
Substance P is present in intrinsic nerves in the intestine and in some extrinsic sensory nerves. It can be released from these nerves to act on the muscle layers and on other enteric neurons. Immunohistochemical studies show that the enteric substance P neurons are short and branch profusely to supply all intestinal layers. Pharmacological studies indicate that enteric substance P neurons receive inputs from enteric cholinergic interneurons. This suggests that these neurons are part of multineuronal nerve pathways in the intestine. The substance P neurons are not essential for the enteric reflexes which subserve peristalsis but they appear to modulate these reflexes.
P物质存在于肠道的内在神经以及一些外在感觉神经中。它可从这些神经释放出来，作用于肌层和其他肠神经元。免疫组织化学研究表明，肠道P物质神经元较短且分支丰富，为肠道各层提供神经支配。药理学研究表明，肠道P物质神经元接受来自肠道胆碱能中间神经元的输入。这表明这些神经元是肠道多神经元神经通路的一部分。P物质神经元对于参与蠕动的肠道反射并非必不可少，但它们似乎能调节这些反射。
