Scheulen M E, Schmidt C G
Dtsch Med Wochenschr. 1982 Oct 29;107(43):1640-4. doi: 10.1055/s-2008-1070180.
Raynaud's phenomenon was observed in 8 out of 271 patients with malignant testicular tumours during or up to 14 months after combined cytostatic treatment. All patients with Raynaud's phenomenon were part of a group of 30 people having received vinblastine in a total dose of at least 2 mg/kg and bleomycin in a dose of 10 mg/kg. There were no other hints of Raynaud's syndrome from the history or chemical pathology. Compared to the experience of other authors Raynaud's phenomenon was observed less frequently and only at dosages of vinblastine and bleomycin considerably higher. This may possibly be due to use of steroids during combined cytostatic treatment with vinblastine and bleomycin.
在271例恶性睾丸肿瘤患者中，有8例在联合细胞抑制治疗期间或治疗后长达14个月出现雷诺现象。所有出现雷诺现象的患者均属于一组30人，他们接受的长春碱总剂量至少为2mg/kg，博来霉素剂量为10mg/kg。病史或化学病理学检查未发现其他雷诺综合征迹象。与其他作者的经验相比，雷诺现象的发生率较低，且仅在长春碱和博来霉素剂量显著更高时出现。这可能是由于在长春碱和博来霉素联合细胞抑制治疗期间使用了类固醇。
