Rumpf P, Schacht U, Palomba P, Kremer K, Borchard E
Chir Forum Exp Klin Forsch. 1977 Apr:58-62.
180 Wistar-rats were daily exposed to 30 and 100 mg MNNG/1000 ccm tapwater. After an exposure of 7 weeks a truncal vagotomy with pyloroplasty or a Billroth II-resection was performed in 25 animals of each dosage-group. 80 rats were not operated. The incidence of carcinomas in the Billroth II-rats of both dosage-groups was evidently higher than in the exposed controls. In the vagotomized rats an increased occurrence of carcinomas could not be observed.
180只Wistar大鼠每天接触30毫克和100毫克/1000立方厘米自来水的MNNG。暴露7周后，每个剂量组的25只动物进行了幽门成形术或毕罗Ⅱ式切除术的迷走神经切断术。80只大鼠未做手术。两个剂量组的毕罗Ⅱ式大鼠的癌症发生率明显高于暴露对照组。在迷走神经切断的大鼠中，未观察到癌症发生率增加。
