Lanoir J, Soghomonian J J, Cadenel G
Exp Brain Res. 1982;48(1):137-43. doi: 10.1007/BF00239581.
The uptake of tritiated gamma-aminobutyric acid (3H-GABA) in the oculomotor nucleus of the cat was studied, using light and electron microscopic examination of radioautograms after intracerebral in vivo administration of the amino-acid. A glial uptake by oligodendrocytes was seen together with a neuronal uptake of the tracer in a certain type of axon terminals found in synaptic contact with both dendrites and soma, some of them exhibiting all the ultrastructural features of motoneurons. Previous neurochemical, electrophysiological and immunocytochemical studies indicate that GABA might well be the inhibitory neurotransmitter in the vestibuloocular reflex arc. The present results show that a morphological substrate exists for the presumed postsynaptic GABAergic inhibition of ocular motoneurons, at least in the oculomotor nucleus of the cat.
利用体内脑内注射该氨基酸后对放射自显影片进行光镜和电镜检查，研究了猫动眼神经核中氚标记的γ-氨基丁酸（3H-GABA）的摄取情况。在与树突和胞体均有突触联系的某些类型轴突终末中，观察到少突胶质细胞对胶质的摄取以及示踪剂的神经元摄取，其中一些轴突终末呈现出运动神经元的所有超微结构特征。先前的神经化学、电生理和免疫细胞化学研究表明，GABA很可能是前庭眼反射弧中的抑制性神经递质。目前的结果表明，至少在猫的动眼神经核中，存在假定的眼运动神经元突触后GABA能抑制的形态学基础。
