Burgess M J, Coyle J
J Electrocardiol. 1982 Oct;15(4):335-44. doi: 10.1016/s0022-0736(82)81006-6.
In 25 pentobarbital anesthetized dogs we measured refractory periods (RPs) of regularly driven complexes and premature ventricular depolarizations (PVDs) with a range of coupling intervals or of regularly driven complexes and the complex following the PVD, i.e. the postextrasystolic depolarization (PED). Measurements were made during control periods and during occlusion of a branch of the left anterior descending coronary artery. The difference in control and occlusion RPs was less following some PVDs with short coupling intervals than following other PVDs with longer coupling intervals. Variations in the coupling interval of PVDs had less effect on RPs of the PVDs in ischemic than in nonischemic tissue. RPs of PEDs were prolonged with respect to RPs of regularly driven complexes in both ischemic and nonischemic tissue, but the prolongation in ischemic tissue was significantly greater than that in nonischemic tissue, 8 +/- 4 msec and 2 +/- 2 msec respectively, p less than .001. The difference in effect of PVDs on RPs of ischemic and nonischemic tissue results in greater disparity of refractoriness between ischemic and nonischemic tissue following some long coupling interval PVDs than following some PVDs with shorter coupling intervals. In addition the greater prolongation of RPs of PEDs in ischemic than in nonischemic tissue can result in increased disparity in RPs than the disparity between ischemic and nonischemic tissue present during regular drive.
在25只戊巴比妥麻醉的犬中，我们测量了正常驱动复合波和室性早搏（PVD）的不应期（RP），其具有一系列的联律间期，或者测量了正常驱动复合波以及PVD后的复合波，即早搏后去极化（PED）。在对照期以及左前降支冠状动脉分支闭塞期间进行测量。与其他联律间期较长的PVD相比，一些联律间期较短的PVD在对照和闭塞时RP的差异更小。PVD联律间期的变化对缺血组织中PVD的RP的影响小于对非缺血组织的影响。在缺血和非缺血组织中，PED的RP相对于正常驱动复合波的RP均延长，但缺血组织中的延长明显大于非缺血组织，分别为8±4毫秒和2±2毫秒，p<0.001。PVD对缺血和非缺血组织RP的影响差异导致一些长联律间期PVD后缺血和非缺血组织之间的不应期差异大于一些联律间期较短的PVD后。此外，缺血组织中PED的RP延长幅度大于非缺血组织，这可能导致RP差异增加，大于正常驱动期间缺血和非缺血组织之间的差异。
