Gwee M C
Med Hypotheses. 1982 Aug;9(2):157-62. doi: 10.1016/0306-9877(82)90131-1.
Pregnant women, especially those in their third trimester, are particularly susceptible to tetracycline-induced fatty liver. Experimental evidence obtained in rats suggest that the precipitous fall in maternal liver choline concentration nearing the end of pregnancy could lead to a severe reduction in the lipotropic activity of the liver. It is hypothesised that the liver in this state will be at much greater risk of developing fatty degeneration, especially if it is exposed to hepatotoxic agents such as tetracycline.
孕妇，尤其是处于孕晚期的孕妇，特别容易受到四环素诱导的脂肪肝影响。在大鼠身上获得的实验证据表明，临近妊娠末期母体肝脏胆碱浓度的急剧下降可能导致肝脏促脂活性严重降低。据推测，处于这种状态的肝脏发生脂肪变性的风险要高得多，特别是如果它接触到四环素等肝毒性药物。
