Sonawane B R, Goldman A S
Proc Soc Exp Biol Med. 1981 Nov;168(2):175-9. doi: 10.3181/00379727-168-41255.
Phenytoin administered to pregnant mice during the critical embryonic period of palatal differentiation produced 50% cleft palates in the Ajax (A/J) strain compared to 1.6% clefts in the C57BL/6 (B6) strain of mice. Furthermore, a single maternal injection of phenytoin produced a significantly greater and more persistent decrease in fetal palatal RNA and protein synthesis in the sensitive A/J strain compared to that in the insensitive B6 strain of mice. Thus, these differential effects of phenytoin on RNA and protein synthesis are associated with the differential susceptibility to the teratogenic action of phenytoin in the two strains.
在腭部分化的关键胚胎期给怀孕小鼠注射苯妥英钠，与C57BL/6（B6）品系小鼠1.6%的腭裂发生率相比，Ajax（A/J）品系小鼠的腭裂发生率达50%。此外，与不敏感的B6品系小鼠相比，单次母体注射苯妥英钠后，敏感的A/J品系小鼠胎儿腭部RNA和蛋白质合成的减少幅度更大且持续时间更长。因此，苯妥英钠对RNA和蛋白质合成的这些差异效应与两个品系对苯妥英钠致畸作用的不同易感性有关。
