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P物质及较短类似物对大鼠体温的影响。

Effects of substance P and shorter analogs on body temperature in the rat.

作者信息

Richter R, Oehme P

出版信息

Acta Biol Med Ger. 1982;41(7-8):725-7.

PMID:6183855
Abstract

The thermoregulatory effects of intraperitoneally administered substance P (SP1-11) (250 micrograms/kg), or equimolar quantities of SP1-4 and SP5-11 were studied in conscious rats at an ambient temperature of 4 degrees C. SP1-11 produced hypothermia, whereas SP1-4 and SP5-11 had no influence. The hypothermic effect of SP1-11 was partially antagonized by naloxone. Thus, an opiate-dependent step seems to be involved in the action of SP1-11.

摘要

在环境温度为4摄氏度的清醒大鼠中，研究了腹腔注射P物质（SP1 - 11）（250微克/千克）或等摩尔量的SP1 - 4和SP5 - 11的体温调节作用。SP1 - 11可导致体温过低，而SP1 - 4和SP5 - 11则无影响。纳洛酮可部分拮抗SP1 - 11的体温过低作用。因此，SP1 - 11的作用似乎涉及一个阿片类物质依赖步骤。

相似文献

1
Effects of substance P and shorter analogs on body temperature in the rat.P物质及较短类似物对大鼠体温的影响。
Acta Biol Med Ger. 1982;41(7-8):725-7.
2
[Differences in activity between substance P and substance P-heptapeptide as studied on the phenomenon of "gut dependence" in rats (author's transl)].
Pharmazie. 1982 May;37(5):368-9.
3
Modulation of kainic acid-induced activity in the mouse spinal cord by the amino terminus of substance P: sensitivity to opioid antagonists.P物质氨基末端对红藻氨酸诱导的小鼠脊髓活动的调节：对阿片类拮抗剂的敏感性。
J Pharmacol Exp Ther. 1993 Apr;265(1):159-65.
4
[On the role of substance P in thermoregulation of normotensive and spontaneously hypertensive rats (author's transl)].
Pharmazie. 1982 Feb;37(2):134-6.
5
[Effects of substance P and its fragments on microhemodynamics in animal experiments].[P物质及其片段对动物实验中微循环动力学的影响]
Biull Eksp Biol Med. 1990 Feb;109(2):113-5.
6
An approach to the elucidation of self-regulatory mechanism of substance P action. I. Synthesis and biological properties of pentapeptides related both to the substance P C-terminal fragment and enkephalins.一种阐明P物质作用的自我调节机制的方法。I. 与P物质C末端片段和脑啡肽相关的五肽的合成及生物学特性。
Pol J Pharmacol Pharm. 1982;34(1-3):63-8.
7
[Effect of substance P and its N-terminal fragment on the components of the normal microcirculatory system and under stress].[P物质及其N端片段对正常微循环系统各组成部分及应激状态下的影响]
Fiziol Zh SSSR Im I M Sechenova. 1989 May;75(5):709-14.
8
Hypothermic effect of GABA in conscious restrained rats and its modification by monoaminergic blocking drugs.
Methods Find Exp Clin Pharmacol. 1987 Apr;9(4):225-31.
9
Prevention of stress-induced involution of the thymus in rats by substance P (SP1-11) and its N-terminal fragment SP1-4.
Pharmazie. 1987 Jan;42(1):34-6.
10
Interaction between opioid agonists and neurotensin on thermoregulation in the rat. I. Body temperature.
J Pharmacol Exp Ther. 1995 Jul;274(1):284-92.

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