Sandström E, Jonsson A, Holterman M, Wallmark G
Acta Derm Venereol. 1982;62(5):419-24.
The rate of reinfection after treatment was studied in four groups of patients. The first group of 100 patients were evaluated retrospectively after treatment with 1.0 g ampicillin twice followed by two re-examinations over a 2-week period during which time intercourse was prohibited. The second and third prospectively groups consisted of 100 and 200 patients respectively, treated with 1 g ampicillin twice and 1.4 g pivampicillin + probenecid respectively, with re-examinations at intervals of 1 week and 4 weeks after treatment. In these two groups sexual intercourse was allowed during the last 10 days of the follow-up period. The fourth study group consisted of all patients infected with gonococci having MIC greater than or equal to 0.3 micrograms/ml for ampicillin and/or benzylpenicillin, who were treated with 1 g ampicillin twice during the period of 1973-76. In the first group no positive cultures were obtained at re-examination. In groups two and three, 35 out of 300 (12%) were found to have positive cultures at re-examination. Some of these were probably treatment failures. The failure rate in group four was found to be 20%, indicating that the treatment regimen used left a narrow therapeutic margin. However, the risk of re-infection, in this urban clinic, seems to be higher than the risk of treatment failure which would have remained undetected had sexual intercourse been forbidden.
对四组患者治疗后的再感染率进行了研究。第一组100例患者在接受两次1.0 g氨苄西林治疗后进行回顾性评估，随后在2周内进行两次复查，在此期间禁止性交。第二组和第三组为前瞻性研究组，分别有100例和200例患者，分别接受两次1 g氨苄西林治疗和1.4 g匹氨西林+丙磺舒治疗，治疗后分别在1周和4周进行复查。在这两组中，随访期的最后10天允许性交。第四研究组由所有对氨苄西林和/或苄青霉素的最低抑菌浓度大于或等于0.3微克/毫升的淋球菌感染患者组成，他们在1973 - 1976年期间接受两次1 g氨苄西林治疗。第一组复查时未获得阳性培养结果。在第二组和第三组中，300例中有35例（12%）复查时培养结果为阳性。其中一些可能是治疗失败。第四组的失败率为20%，表明所用治疗方案的治疗窗较窄。然而，在这家城市诊所，再感染的风险似乎高于治疗失败的风险，如果禁止性交，治疗失败可能仍未被发现。
